The Angeles University Foundation School of Medicine (AUF-SOM) was established in June 1983 by the authority of the Board of Medical Education and the Department of Education, Culture, and Sports with Dr. Rodolfo C. Dimayuga as founding dean, Dr. Presentacion C. Peralta as assistant dean and concurrently school secretary, and a faculty of 18, eight of whom boast of 20 years teaching experience. The AUF-SOM was initially housed in the AUF San Lorenzo Ruiz Building until it was gutted down by fire in 1993. This tragedy gave way to the construction of a new health sciences building which now houses the AUF-SOM office, lecture rooms and laboratories.

The AUF-SOM was solely affiliated with Jose B. Lingad Memorial Regional Hospital for the clinical training of students until the establishment of the AUF Medical Center on February 23, 1990. The 125-bed AUFMC is the only private tertiary teaching, training and research hospital in Central Luzon which serves as the base hospital of AUF medical and allied medical students.Acknowledged for their expertise and integrity, the AUF-SOM faculty play an active role in elevating the standards of Philippine medical education through their involvement as accreditors, technical panelists and board specialty examiners.

The AUF Doctor of Medicine program is the only PAASCU accredited program in Central Luzon. It was the first in the region given ISO 9001-2000 certification by TUV-SUD in 2008 and the only one north of Manila that is ISO 9001-2008 certified by TUV-SUD. The AUF Doctor of Medicine program has produced outstanding board performance in the Philippine medical board exam, stellar performance at the Indian Medical Council Screening Test, and a 100% pass rate in the 2014 Nepal Medical Council Screening Test. As a result, an increased number of Indian students are now enrolled in the AUF BS Psychology program leading to the degree Doctor of Medicine.